From being regarded a minor class of RNAs, ncRNAs (non-coding RNAs, mostly antisense) have recently emerged as ubiquitous key players in important life processes in animals, plants, fungi and metazoans. Similarly, 65 small ncRNAs, encoded by the E. coli genome, have been recently identified, and additional ones are being discovered in other bacterial species. Many of these RNAs play key roles in the control of global regulatory networks, e.g. in stress responses.

The team will use its multidisciplinary expertise in the fields of microbial pathogenicity, RNA biology, biochemistry and computational biology. Some team members investigate novel ncRNAs and their targets (mRNA or proteins) in several representative pathogens (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus, and Streptococcus pyogenes). Their roles in the establishment of bacterial pathogenicity will be analysed. Infection studies using cell culture will allow the validation of ncRNAs and respective targets in virulence. Structural and mechanistic aspects of the ncRNAs will elucidate their interaction with the targets. Research on these topics will propose how the regulatory ncRNAs are integrated into the general network of control of stress responses, host adaptation and bacterial virulence. Since the long-term objective of BACRNAs is to generate fundamental knowledge that can be directly applicable for therapeutic purposes to combat bacterial infections, the team expects with this research to identify novel targets for drug design strategies (SME partner).

AntragsstellerIn Universität Wien, Österreich
KoordinatorIn Prof. Renée Schroeder, Department für Biochemie
Anzahl der PartnerInnen 8 Institutionen=Vertragspartner mit 12 Partnergruppen aus Österreich, Frankreich, Israel und Schweden
PUNKT's responsibilities Administrative Leitung des gesamten Projektes. Darunter fallen die Einhaltung und Kontrolle des Projektbudgets, der rechtlichen Verpflichtungen wie dem Reporting, der zeitgerechten Lieferung der Projektergebnisse sowie deren Eigentumsschutz, planen, organisieren und leiten der Konsortialmeetings sowie vermitteln der Projektresultate auf möglichst originelle Art an die geeigneten Zielgruppen
Status 2009 abgeschlossen; LSHG-CT-2005-018618